Description

Different variants of the apolipoprotein E (APOE) gene have been associated with different levels of risk for developing Alzheimer’s disease. This long-term study will gather data in cognitively normal older adults and compare cognitive, behavioral, and physical changes across different APOE variants, or genotypes. We will develop, use, and extensively share critically important resources of cognitive, biomarker, genetic, and related data from cognitively unimpaired 50-90-year-old persons with each common form of APOE, the major Alzheimer’s disease susceptibility gene, representing six levels of risk. We will clarify the impact of APOE, other genetic and non-genetic factors, and their interactions on the predisposition to, protection from and potential prevention of Alzheimer’s disease, inform the design and size of 12 or 24-month prevention trials using biological outcome measurements, and demonstrate the value of extremely promising blood tests in these endeavors. We will provide an extensively shared resource of data, findings, biological samples, and motivated APOE-tested volunteers for the research community, support a wide range of other studies.

Principal Investigators

  • Jessica Langbaum, PhD — Banner Alzheimer’s Institute
  • Eric Reiman, MD — Banner Alzheimer’s Institute
  • Yi Su, PhD — Banner Alzheimer’s Institute
  • Bryan Woodruff, MD — Mayo Clinic Arizona

Funding Sources

R01AG069453

Publications

  • Guo X. A Computational Monte Carlo Simulation Strategy to Determine the Temporal Ordering of Abnormal Age Onset Among Biomarkers of Alzheimer's Disease. IEEE/ACM transactions on computational biology and bioinformatics. 2022 Sep-Oct. PubMed link
  • Chen K. Limitations of clinical trial sample size estimate by subtraction of two measurements. Statistics in medicine. 2022 Mar 30. PubMed link
  • Wang G. Studying APOE ɛ4 Allele Dose Effects with a Univariate Morphometry Biomarker. Journal of Alzheimer's disease : JAD. 2022. PubMed link
  • Wu J. Predicting Tau Accumulation in Cerebral Cortex with Multivariate MRI Morphometry Measurements, Sparse Coding, and Correntropy. Proceedings of SPIE--the International Society for Optical Engineering. 2021 Nov. PubMed link
  • Krell-Roesch J. Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023 Oct. PubMed link
  • Shah J. Deep residual inception encoder-decoder network for amyloid PET harmonization. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Dec. PubMed link
  • Wu J. INVESTIGATING THE EFFECT OF TAU DEPOSITION AND APOE ON HIPPOCAMPAL MORPHOMETRY IN ALZHEIMER'S DISEASE: A FEDERATED CHOW TEST MODEL. Proceedings. IEEE International Symposium on Biomedical Imaging. 2022 Mar. PubMed link
  • Suchy-Dicey A. Volume atrophy in medial temporal cortex and verbal memory scores in American Indians: Data from the Strong Heart Study. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023 Jun. PubMed link
  • Wu J. Improved Prediction of Amyloid-β and Tau Burden Using Hippocampal Surface Multivariate Morphometry Statistics and Sparse Coding. Journal of Alzheimer's disease : JAD. 2023. PubMed link
  • Protas H. Individualized network analysis: A novel approach to investigate tau PET using graph theory in the Alzheimer's disease continuum. Frontiers in neuroscience. 2023. PubMed link
  • Malek-Ahmadi M. Plasma NfL is associated with the APOE ε4 allele, brain imaging measurements of neurodegeneration, and lower recall memory scores in cognitively unimpaired late-middle-aged and older adults. Alzheimer's research & therapy. 2023 Apr 10. PubMed link
  • Wu J. A Surface-Based Federated Chow Test Model for Integrating APOE Status, Tau Deposition Measure, and Hippocampal Surface Morphometry. Journal of Alzheimer's disease : JAD. 2023. PubMed link
  • Krell-Roesch J. Plasma-derived biomarkers of Alzheimer's disease and neuropsychiatric symptoms: A community-based study. Alzheimer's & dementia (Amsterdam, Netherlands). 2023 Jul-Sep. PubMed link
  • Ramos C. Psychological Status of the Participants in Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Colombia. Journal of Alzheimer's disease : JAD. 2023. PubMed link
  • Kwak MG. Self-Supervised Contrastive Learning to Predict the Progression of Alzheimer's Disease with 3D Amyloid-PET. Bioengineering (Basel, Switzerland). 2023 Sep 28. PubMed link
  • Dong Q. Correlation studies of Hippocampal Morphometry and Plasma NFL Levels in Cognitively Unimpaired Subjects. IEEE transactions on computational social systems. 2023 Dec. PubMed link
  • Haney MS. APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia. Nature. 2024 Apr. PubMed link