The National Institute on Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS) is the largest collection of multiplex AD families recruited and longitudinally assessed worldwide. Since 2003, the central goal of this cohort has been to broadly support genetic research by making clinical and genomic data and biological samples rapidly available to the AD research community to support the development of therapies to treat or prevent AD. The use of multiplex families to understand genetic susceptibility to AD began with early‐onset forms. 

Over the length of the project, NIA AD-FBS (formerly LOAD study) have identified environmental,
health-related and genetic risk factors of disease and predictors of disease progression by collecting longitudinal data on cognitive performance, emotional health, independence in daily activities, blood pressure, cardiovascular status in this both early and late onset, multi-ethnic cohort. Sample collection includes DNA, Plasma, PBMC and Paxgene.