HRS – APOE and Serotonin Transporter Alleles

Since 1992, the Health and Retirement Study (HRS, a cooperative agreement between the National Institute on Aging (NIA) and the University of Michigan, NIA U01AG009740) has been the largest, representative longitudinal study of Americans over age 50. Built on a national probability sample with oversamples of minorities, it is the model for a network of harmonized international longitudinal studies of work, health, social, psychological, family and economic status through critical life transitions and trajectories related to retirement, economic security, health and function, social and behavioral function and support systems. Core interviews take place every two years and are supplemented by mail surveys, biomarker collections, administrative linkages, and other sources.

Provided in this dataset is a csv file containing APOE genotypes and HTTLPR calls for 19,193 total subjects. 17,237 subjects’ APOE genotypes were collected directly using a TaqMan allelic discrimination SNP assay at the Center for Inherited Disease Research (CIDR) Genetic Resources Core Facility (GRCF) and Fragment Analysis Facility (FAF) at Johns Hopkins University. 1,956 subjects’ APOE genotypes were imputed from a preexisting genotype array to the 1000G (Phase3 v5) reference panel. 17,364 subjects’ HTTLPR short and long alleles were measured using PCR.