The Adult Changes in Thought (ACT) study is a longitudinal prospective cohort study that began in 1994. Participants are randomly selected from Seattle area members of Group Health aged 65 years or older. Participants are cognitively intact at study enrollment, defined operationally as a CASI (Cognitive Abilities Screening Instrument) score…
Cohort Country: United States of America
University of Miami (MIA)
Each affected individual met NINCDS-ADRDA criteria for probable or definite AD with age at onset greater than 60 years, as determined from specific probe questions within the clinical history provided by a reliable family informant or from documentation of significant cognitive impairment in the medical record. Cognitively healthy controls were…
Washington Heights and Inwood Community Aging project (WHICAP)
Unrelated Nondemented (initially), 65 years of age or older including non‐Hispanic whites (32%), African Americans (28%), and Caribbean Hispanics from the Dominican Republic (44%). Assessments include: medical evaluation, cognitive testing, MRI, PET scan and biomarkers studies. For more information about this cohort, see the WHICAP study.
Vanderbilt University (VAN)
The UM/VU dataset contains 1,186 cases and 1,135 CNEs (new and previously published) ascertained at the University of Miami and Vanderbilt University, including 409 autopsy-confirmed cases and 136 controls. An additional 16 cases were included and 34 controls excluded from the data analyzed in the prior study. Each affected individual…
National Institute of Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS)
The FBS collection is a longitudinal, multi-center late onset AD sibling genetics initiative. This NIA-funded study began in 2,002 and maintains DNA and cell lines on families with 2 or more siblings with AD (at least one probable or confirmed AD) (n=5,291). A third family member who is either affected…
National Centralized Repository for Alzheimer’s Disease and Related Dementias Family (NCRAD Family)
The National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD) family cohort was started in 1990 and consists of families with two or more members with early or late onset AD and related dementias. This collection maintains DNA and cell lines on affected family members and unaffected relatives (typically…
Indianapolis-Ibadan (IIAA/IIBD)
The Indianapolis-Ibadan Dementia Project, established in 1991, is a longitudinal prospective population-based comparative epidemiological study of the prevalence and incidence rates and risk factors for Alzheimer’s disease and other age associated dementias. Enrollment of community-dwelling elderly (age>65 years) African Americans living in Indianapolis and Yoruba living in Ibadan, Nigeria employed…
Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA)
Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA) included 683 at-risk family members from 242 AD-affected families of Caribbean Hispanic descent. These families have 2 or more individuals affected with Alzheimer’s disease. A system of recruitment was also set up in the Dominican Republic with the help of several local physicians,…
Alzheimer’s Disease Neuroimaging Initiative (ADNI)
ADNI is a global research study that actively supports the investigation and development of treatments that slow or stop the progression of AD. In this multisite longitudinal study, researchers at 63 sites in the US and Canada track the progression of AD in the human brain with clinical, imaging, genetic…
NIA Alzheimer’s Disease Research Centers (ADRC)
The NIA ADRC cohort included subjects ascertained and evaluated by the clinical and neuropathology cores of the 32 NIA-funded ADRCs. Data collection is coordinated by the National Alzheimer’s Coordinating Center (NACC). NACC coordinates collection of phenotype data from the 32 ADRCs, cleans all data, coordinates implementation of definitions of AD…