Description
131 families with LOAD (751 individuals) were ascertained and evaluated through the University of Washington Alzheimer Disease Research Center. Clinical and neuropathological assessments of cases and controls, including blood sampling, medical record reviews, brain autopsies, and genetic analyses were performed under protocols approved by the institutional review boards of the University of Washington and the Seattle Veterans Affairs Puget Sound Health Care System.
Related Datasets
- This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common…
- This GWAS dataset, ADC3, is the third set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing…
- Many regions of the human genome present challenges that prohibit scientists from discovering potential disease-causing mutations. We developed methods to characterize mutations in these regions to rescue mutations that are…
Related Studies
- Background An initiative in response to the National Alzheimer’s Project Act (NAPA) has been working towards new biological insights and cures for Alzheimer’s Disease (AD) since its introduction by NIH…
- The ADGC is a large U.S. based consortium formed to collaboratively use the collective resources of the AD research community to resolve Alzheimer’s disease (AD) genetics. Working with the National…
- GWAS studies were very successful in identifying genetic loci associated with AD risk. However, these studies could not point to the actual causal variant. In this study, WES and/or WGS…
- In this study, a family-based genome-wide association study was performed for AAO of late-onset AD in whole exome sequence data generated in multigenerational families with multiple AD cases (n=77). Single…
- Many regions of the human genome present challenges that prohibit scientists from discovering potential disease causing mutations. We developed methods to characterize mutations in these regions to rescue mutations that…
- The National Institute on Aging Alzheimer's Disease Family Based Study (NIA AD-FBS) is the largest collection of multiplex AD families recruited and longitudinally assessed worldwide. Since 2003, the central goal…
Related Sample Sets
- The initial phase of the ADSP research plan is called the Discovery Phase. Samples were selected from well-characterized study cohorts of individuals with or without an AD diagnosis and the…
- FASe Family samples were sequenced at Genentech, MGI and Otogenetics on the HiSeq2000 machine. 715 samples were sequenced using the Agilent WES v5 capture region, 164 samples were using the…
- This is a family design study. Samples were sequenced at Department of Genome Sciences, University of Washington on the HiSeq2000 machine. 77 samples were sequenced using the Roche SeqCap EZ…
- FASe_WGS samples were whole-genome sequenced at Broad either on the HiSeqX or HiSeq2000/2500 machine. Samples in either format (BAM files from hg37 build and FASTQ files) were sent to GCAD…
- The ADC3 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Human OmniExpress (HumanOmniExpress-12v1_A) BeadChip which captures genotype data on…
- Provided here are variant calls in VCF format for 14,526 samples derived from the ADSP whole-exome and whole-genome sequencing dataset (available via DSS: NG00067).
- A total of 999 NIA-FBS cohort samples were sequenced at NYGC on the Illumina HiSeqX platform. The BAM files were sent to GCAD for processing through the VCPA1.1 pipeline. A…