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Description

The NCRAD Families sample set was genotyped at the Children’s Hospital of Philadelphia using the Illumina Infinium GSAMD-24v2-0_20024620_A1 BeadChip which captures genotype data on 759,993 genomic SNPs. These families are not evaluated in person. Family history and demographic data are collected and updated annually. Clinical information is obtained through the request for medical records which are reviewed by a central neurologist and where possible, diagnosis is determined by NINCDS-ADRDA Criteria. A standardized telephone cognitive battery is completed, where possible, every 2 years. These data are also reviewed centrally along with the medical records. Subjects are contacted annually for updates on diagnoses within their family. Brain donation is coordinated for interested participants and performed centrally. Brain tissue is available from some NCRAD Family Study participants.

Sample Summary per Data Type

Sample SetAccessionData TypeNumber of Samples
NCRAD Families GWAS GSA snd10037GWAS698

Available Filesets

NameAccessionLatest ReleaseDescription
NCRAD Families GWASfsa000032NG00117.v1GWAS, Covariates, Phenotypes

View the File Manifest for a full list of files released in this dataset.

The NCRAD Families sample set was genotyped at the Children's Hospital of Philadelphia using the Illumina Infinium GSAMD-24v2-0_20024620_A1 BeadChip which captures genotype data on 759,993 genomic SNPs.

Sample SetAccession NumberNumber of Subjects
NCRAD Families GWAS GSA snd10037698
Consent LevelNumber of Subjects
GRU-IRB-PUB698

Visit the Data Use Limitations page for definitions of the consent levels above.

Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer’s Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

Use the study-specific acknowledgement statements below (as applicable):

For investigators using any data from this dataset:

Please cite/reference the use of NIAGADS data by including the accession NG00117.

For investigators using NCRAD Family Study (sa000025) data:

Samples from the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD), which receives government support under a cooperative agreement grant (U24AG021886) awarded by the National Institute on Aging (NIA), were used in this study. We thank the participants and their families, whose help and participation made this work possible. Quality control procedures and data preparation on the GWAS was conducted by the Alzheimer’s Disease Genetics Consortium (ADGC) (UO1AG032984) and the NIA Genetics of Alzheimer’s Disease Storage Site (NIAGADS) (U24-AG041689), both funded by NIA.