Description
The NCRAD Family Study began in 1990 and continues to actively recruit and follow subjects. Families with two or more living, biologically related, members with early or late onset AD and related dementias are enrolled. Samples are obtained from affected family members and unaffected relatives (typically over age 60). Neuropathology has been completed in over 700 NCRAD Family Study participants and brain tissue is available for over 250 of those individuals.
The NCRAD Families sample set was genotyped at the Children’s Hospital of Philadelphia using the Illumina Infinium GSAMD-24v2-0_20024620_A1 BeadChip which captures genotype data on 759,993 genomic SNPs.
Sex
Total number of samples: 698
Female 424 60.7 %
Male 274 39.3 %
Race
Total number of samples: 698
| Black or African American | 8 |
| White | 678 |
| Other | 2 |
| NA | 10 |
Ethnicity
Total number of samples: 698
Not Hispanic or Latino
657
94.1%
Hispanic or Latino
8
1.1%
Not Applicable/Not Available
33
4.7%
Diagnosis
Total number of samples: 698
| AD | ||
|---|---|---|
| Control | 34 | 4.9% |
| Case | 253 | 36.2% |
| Other | 19 | 2.7% |
| Other | ||
|---|---|---|
| Other | 188 | 26.9% |
| NA | ||
|---|---|---|
| Unknown | 204 | 29.2% |
APOE
Total number of samples: 698
- 223 (0.4%)
- 2338 (5.4%)
- 2428 (4.0%)
- 33276 (39.5%)
- 34282 (40.4%)
- 4471 (10.2%)