Description
Data Available
To access this data, please log into DSS and submit an application.
Within the application, add this dataset (accession NG00147) in the “Choose a Dataset” section.
Once approved, you will be able to log in and access the data within the DARM portal.
Description
The ANGI GWAS dataset includes demographics, APOE genotype, and GWAS data for participants from the ANGI cohort. This dataset also includes amyloid PET scan results (positive, negative, uninterpretable, not yet reported), level of cognitive impairment (no impairment, MCI, Dementia), year of onset of cognitive impairment, most etiological causes of impairment (pre and post scan), year enrolled in IDEAS, year of amyloid PET scan, year of post-PET visit, MMSE score, and type of MCI (if applicable, amnestic or non-amnestic). Request additional ANGI data including IDEAS imaging and clinical data through the IDEAS website.
Sample Summary per Data Type
Sample Set | Accession | Data Type | Number of Samples |
---|---|---|---|
ANGI GWAS | snd10081 | Genotyping SNP Array | 1,647 |
Available Filesets
Name | Accession | Latest Release | Description |
---|---|---|---|
ANGI: GWAS, Phenotype files | fsa000102 | NG00147.v1 | GWAS, Phenotypes |
View the File Manifest for a full list of files released in this dataset.
Subject Information
The first release includes quality controlled GWAS data on 1,647 participants from the ANGI cohort. It also includes phenotypes provided by the ANGI Study.
Sample Set | Accession Number | Number of Subjects |
---|---|---|
ANGI GWAS | snd10081 | 1,647 |
Related Studies
Consent Levels
Consent Level | Number of Subjects |
---|---|
GRU-IRB-PUB | 1,647 |
Visit the Data Use Limitations page for definitions of the consent levels above.
Approved Users
- Investigator:Cruchaga, CarlosInstitution:Washington University School of MedicineProject Title:The Familial Alzheimer Sequencing (FASe) ProjectDate of Approval:May 9, 2024Request status:ApprovedResearch use statements:Show statementsTechnical Research Use Statement:The goal of this study is to identify new genes and mutations that cause or increase risk for Alzheimer disease (AD), as well as protective factors. Individuals and families were selected from the Knight-ADRC (Washington University) and the NIA-LOAD study. Only families with at least three first-degree affected individuals were included. Families with pathogenic variants in the known AD or FTD genes, or in which APOE4 segregated with disease were excluded. At least two cases and one control were selected per family. Cases had an age at onset (AAO) after 65 yo and controls had a larger age at last assessment than the latest AAO within the family. Whole exome (WES) and whole genome sequencing (WGS) was generated for 1,235 individuals (285 families) that together with data from our collaborators and the ADSP family-based cohort (3,449 individuals and 757 families) will provide enough statistical power to identify new genes for AD. Dr. Tanzi (Harvard Medical School) will provide WGS from 400 families from the NIMH Alzheimer disease genetics initiative study. We will perform single variant and gene-based analyses to identify genes and variants that increase risk for disease in AD families. Single variant analysis will consist of a combination of association and segregation analyses. We will run family-based gene-based methods to identify genes that show and overall enrichment of variants in AD cases. We will also look for protective and modifier variants. To do this we will identify families loaded with AD cases, that also include individuals with a high burden of known risk variants but that do not develop the disease (escapees). We will use the sequence data and the family structure to identify variants that segregate with the escapee phenotype. The most promising variants and genes will be replicated in independent datasets (ADSP case-control, ADNI, Knight-ADRC, NIA-LOAD ). We will perform single variant and gene-based analyses to replicate the initial findings, and survival analysis to replicate the protective variants. We will select the most promising variants/genes for functional studiesNon-Technical Research Use Statement:Family-based approaches led to the identification of disease-causing Alzheimer’s Disease (AD) variants in the genes encoding APP, PSEN1 and PSEN2. The identification of these genes led to the A?-cascade hypothesis and to the development of drugs that target this pathway. Recently, we have identified rare coding variants in TREM2, ABCA7, PLD3 and SORL1 with large effect sizes for risk for AD, confirming that rare coding variants play a role in the etiology of AD. In this proposal, we will identify rare risk and protective alleles using sequence data from families densely affected by AD. We hypothesize that these families are enriched for genetic risk factors. We already have sequence data from 695 families (2,462 individuals), that combined with the ADSP and the NIMH dataset will lead to a dataset of more than 1,042 families (4,684 individuals). Our preliminary results support the flexibility of this approach and strongly suggest that protective and risk variants with large effect size will be found, which will lead to a better understanding of the biology of the disease.
Acknowledgement
Acknowledgment statement for any data distributed by NIAGADS:
Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer’s Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.
Use the study-specific acknowledgement statements below (as applicable):
For investigators using any data from this dataset:
Please cite/reference the use of NIAGADS data by including the accession NG00147.
For investigators using Amyloid Neuroimaging and Genetics Initiative (ANGI) (sa000049) data:
The ANGI study is supported by the Alzheimer’s Association Grant ANGI/IDEAS-17-497186. We thank the Alzheimer’s Association for their support and the ANGI study participants for their contribution to the study. We would also like to acknowledge the Imaging Dementia – Evidence for Amyloid Scanning Study (iDEAS) from whom amyloid imaging and other clinical data were obtained.
Related Publications
Rabinovici GD., Gatsonis C., et al. Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia. JAMA. 2019 Apr. doi: 10.1001/jama.2019.2000. PubMed link