Are you going to be at the American Society for Human Genetics (ASHG) 2024 Annual Meeting being held in Denver, Colorado from this Tuesday, 11/05/24, to Saturday, 11/09/24? The ADSP and NIAGADS will be there too! Check out where you can see the ADSP and NIAGADS in action below: ADSP…
News
New Data Available in the Alzheimer’s GenomicsDB!
This release expands the database to include: ADSP 36K R4 Variants and Annotations New and updated records for each R4 variant are now available. These include the most recent ADSP annotations, as well as updated associations from the NHGRI-EBI GWAS Catalog. Search for a specific variant of interest to browse…
ADSP Umbrella Dataset October 2024 Update: New Files Added to NG00067
New files have been released in ng00067.v13 for the R2 20K Whole Exome Sequencing (WES) and R3 17K and R4 36K Whole Genome Sequencing (WGS). To apply for this dataset, see our application guide. For those who already have access to NG00067, files will be automatically available in compliance with…
NIAGADS Data Discovery Portal Beta Release: Gen3 Enables Exploration of the ADSP Dataset
One of the first challenges researchers face when accessing data is determining if the dataset has information relevant to their research question. The NIAGADS team is committed to reducing this burden for researcher through NIAGADS Open Access, a suite of knowledge bases to help explore the NIAGADS data collection and…
A Year of Support and Resource Improvements at NIAGADS
The last 12 months have been a year of growth for user support and resources at NIAGADS. The team was hard at work developing and improving documentation, tutorials, and more. Ticket System NIAGADS now has a dedicated ticket system for users to submit questions and technical issues. The ticket system…
Looking to Explore AD Genomics? Check out NIAGADS Alzheimer’s Genomics Database
The Alzheimer’s Genomics Database is a user-friendly AD-centric interactive knowledgebase and genome browser, which provides unrestricted access to GWAS summary statistics from the NIAGADS repository, as well as to annotated variants called from ongoing the Alzheimer’s Disease Sequencing Project’s (ADSP) joint-genotype calling efforts. We sat down with Dr. Emily Greenfest-Allen,…
Updates to the Data Access Request Management (DARM) and Data Sharing Service (DSS) Portals
The NIAGADS team has been hard at work writing and testing code to improve user experience in the DARM and DSS portals. We are happy to share that the following features are now available to users: DARM Administrator Role Added – Investigators can now designate “Administrators” to complete data applications…
Creating the Largest Joint-Called Whole Exome Sequencing (WES) Dataset for Alzheimer’s Disease (AD)
Over the last 20 years, the technology for DNA sequencing has rapidly evolved, making it possible to sequence individual whole genomes on a large scale. But when trying to find the underlying genetic causes of disease, every sequence donated matters. How can the sequences generated using older technology be reused?…
15 Genotyping Array Datasets From the Alzheimer’s Disease Research Centers (ADRC) Now Available!
We are thrilled to announce the release of 15 much-anticipated genotyping array datasets from participants recruited from the Alzheimer’s Disease Research Centers (ADRC)! These datasets, ADC1 through ADC15, are now available on the NIAGADS Data Sharing Service (DSS). DNA was prepared by the National Centralized Repository for Alzheimer’s Disease and…
Introducing hipFG: A high-throughput harmonization and integration pipeline for genomic annotations, QTLs, and chromatin interactions
A major challenge facing researchers today is the cleanup and harmonization of data for use in their work. As datasets get larger and the types of outputs continue to grow, this problem will continue to grow exponentially. Manually cleaning this data can be time consuming and prone to human error. Addressing…