Over the last 20 years, the technology for DNA sequencing has rapidly evolved, making it possible to sequence individual whole genomes on a large scale. But when trying to find the underlying genetic causes of disease, every sequence donated matters. How can the sequences generated using older technology be reused?…
Category: GCAD
ADSP Releases Additional 19K Whole Genomes via NIAGADS DSS
On October 6, 2022, the Alzheimer’s Disease Sequencing Project (ADSP) released a new dataset comprised of 19,456 newly sequenced genomes together with joint genotype calls totaling 36,361 genomes with previously released genomes. The data release includes sequencing reads in the CRAM file format, individual sample genotype calls in the genomic…
ADSP releases quality-controlled whole-genome data on nearly 17,000 samples
NIAGADS is pleased to announce the release of the Release 3 (R3) WGS ADSP quality-controlled joint genotype called pVCF containing 16,905 samples. Additionally, this release includes a quality-controlled X-chromosome pseudoautosomal region (PAR) pVCF containing 20,503 whole exomes from Release 2 (R2) as well as R3 individual-level VCF structural variant (SV)…
NIAGADS DSS Releases Additional 17K Whole Genomes
NIAGADS is pleased to announce the release of whole genome sequencing (WGS) data from 16,906 samples through the Data Sharing Service (DSS). The data release includes CRAMs, gVCFs, and project-level VCFs across all samples. The pVCF released here is provided as a preview to the formal ADSP quality control that will be released in a few months. Additionally, this release…
NIAGADS DSS Releases 20K Whole Exomes
NIAGADS is pleased to announce the release of 19,922 whole exomes called on GRCh38 through the Data Sharing Service (DSS). Nine different studies contributed to the release, including 10,088 ADSP Discovery Case Control WES samples, 3,144 ADGC African American WES samples, 75 Brkanac Families WES samples, 346 Corticobasal degeneration WES…
Additional ADSP Data Released
We are pleased to announce a new data release on the NIAGADS Data Sharing Service (DSS). The NIAGADS DSS currently hosts ADSP Discovery+ Extension whole genome data from 854 subjects in 159 families and an additional 1433 cases and 1654 controls as well as 809 whole genomes from ADNI-WGS-1. Additional data…
Collaboration with ADNI
In a collaboration with LONI, GCAD has recalled the 809 ADNI-WGS-1 whole genomes using the VCPA 1.0 pipeline and is releasing this data along with the 3985 ADSP whole genomes. Principal Investigators requesting this data must an approved application with ADSP through the DSS as well as ADNI. More information about this…
First Dataset Released
The NIAGADS DSS currently hosts ADSP Discovery+ Extension whole genome data from 854 subjects in 159 families and an additional 1433 cases and 1654 controls as well as 809 whole genomes from ADNI-WGS-1. The first release includes the GATK called CRAMs and gVCFs generated by Genome Center for Alzheimer’s Disease…
NIAGADS DSS is now live!
NIAGADS is pleased to announce that its Data Sharing Service is now live. The NIAGADS DSS hosts genomic data from the Alzheimer’s Disease Sequencing Project (ADSP) and other NIA funded AD genomic studies with approved users in the research community at large. The DSS hosts sequencing data mapped to GRCh38,…