The ADSP Discovery Family-Based Extension Study:

To further assess the genomes in multiply affected families, under funding provided by NHGRI, an additional 427 samples were whole genome sequenced. This included 107 additional samples from families studied under the Discovery Phase, 175 samples from 47 new families, and 145 Hispanic Controls. This portion of the study is called the Discovery Extension Phase. The Family Based Study spans seven cohorts provided by the Alzheimer’s Disease Genetics Consortium (ADGC) and the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.

The ADSP Discovery Case-Control Based Extension Study:

Under funding provided by NHGRI, an additional 3,000 subjects were whole genome sequenced. This included 1,466 cases and 1,534 controls. Of these 1,000 each of Non-Hispanic White (NHW), Caribbean Hispanic (CH), and African American (AA) descent were sequenced. Of these a total of 739 autopsy samples were sequenced [568 cases (500 NHW cases and 68 AA cases) and 171 controls (164 NHW and 7 AA)]. This Case-Control spans 5 cohorts provided by the Alzheimer’s Disease Genetics Consortium (ADGC).

Sequencing for these samples was conducted through three National Human Genome Research Institute (NHGRI) funded Large Scale Sequencing and Analysis Centers (LSACs): Baylor College of Medicine Human Genome Sequencing Center, the Broad Institute, the McDonnell Genome Institute at Washington University. The samples were sequenced on the Illumina HiSeq X Ten platform with 150bp paired-end reads.

Total number of subjects: 3367

Female 2217 65.8 %
Male 1150 34.2 %

Total number of subjects: 3367

Hispanic or Latino
1214
36.1 %
Not Hispanic or Latino
2144
63.7 %
NA
9
0.3 %

Case/Control Study:
Incident AD44813.31%
Prevalent AD98529.25%
No Prevalent or Incident AD165449.12%

Family Based Study:
Definite AD170.50%
Probable AD451.34%
Possible AD40.12%
Family Reported AD20.06%
Family Reported No AD20.06%
No Dementia2005.94%
Other Dementia20.06%
Unknown80.24%

Total number of subjects: 3367