Description
A dried blood spot (DBS) collection in Round 7 (2017) of NHATS provided the biological material for genotyping. Samples were genotyped at Erasmus Medical Center in Rotterdam, Netherlands on the Illumina Infinium Global Screening Array v3.0. The array contains clinical and rare variants ideal for multiethnic populations. After quality control steps removing variants with high (>5%) missingness and individuals with high missingness (>5%), a total of 700,009 variants and 4,006 samples were included in the NHATS genetic dataset. Self-reported primary race/ethnicity with missing values assigned the modal category indicated 729 non-Hispanic Black, 2,962 non-Hispanic White, 223 Hispanic, and 92 other race/ethnicity samples. For detail about each self-reported race/ethnicity group see the NHATS User Guide [https://nhats.org/researcher/nhats/methods-documentation?id=user_guide]. Quality control was performed at the Arking Lab at the Johns Hopkins University and validated independently at the University of Michigan. We include genotyped data (build hg19/GRCh37 plink format), TOPMed imputed data (build GRCh38, vcf format), ancestry-specific analytic groups, as well as recommended sample filtering information. Within ancestry principal components are available from the NHATS study by request.