The WHICAP WES study consists of a multi-ethnic cohort of 4,100 individuals followed over several years. Participants were community-living Medicare recipients 65 years and older recruited from northern Manhattan to participate in the Washington Heights-Inwood Columbia Aging Project. Potential participants were identified based on residence in US Census tracts within the study catchment area. Recruitment occurred in three waves: 1992 (N = 2126), 1999 (N = 2174), and 2009 (N = 2128). Participants completed a baseline assessment and were followed up at 18- to 24-month intervals for up to 25 years. During each session, participants were administered a neuropsychological battery and asked about their general health, functional ability, and medical history and were re‐consented for sharing of genetic information and autopsy. Evaluations were conducted in English or Spanish, based on language preference. The cohort participants were non-demented initially, 65 years of age or older, and comprised of non‐Hispanic whites, African Americans, and Caribbean Hispanics from the Dominican Republic. A consensus diagnosis was derived for each participant by experienced clinicians based on NINCDS‐ADRDA criteria for possible, probable, or definite AD, or moderate or high likelihood of neuropathological criteria of AD.

Every individual with whole‐exome sequencing has at least a baseline and one follow‐up assessment and examination, and for those who have died, the presence or absence of dementia was determined using a brief, validated telephone interview with participant informants: the Dementia Questionnaire (DQ) and the Telephone Interview of Cognitive Status (TICS). 4,100 exome sequenced WHICAP individuals were designated with case or control status. Whole‐exome sequencing of the WHICAP cohort was performed at Columbia University.

Richard P. Mayeux, MD, MSc

Nicole Schupf, Ph.D.

PO1AG07232, R01AG037212, RF1AG054023, UL1TR001873

Data collection and sharing for this project was supported by the Washington Heights-Inwood Columbia Aging Project (WHICAP, PO1AG07232, R01AG037212, RF1AG054023) funded by the National Institute on Aging (NIA) and by the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant Number UL1TR001873. This manuscript has been reviewed by WHICAP investigators for scientific content and consistency of data interpretation with previous WHICAP Study publications. We acknowledge the WHICAP study participants and the WHICAP research and support staff for their contributions to this study.

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Gutierrez J, Guzman V, Khasiyev F, Manly J, Schupf N, Andrews H, Mayeux R, Brickman AM. Brain arterial dilatation and the risk of Alzheimer’s disease. Alzheimers Dement. 2019 May;15(5):666-674. doi: 10.1016/j.jalz.2018.12.018. Epub  2019 Mar 1. PubMed PMID: 30827874; PubMed Central PMCID: PMC6511479.

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Tosto G, Vardarajan B, Sariya S, Brickman AM, Andrews H, Manly JJ, Schupf N, Reyes-Dumeyer D, Lantigua R, Bennett DA, De Jager PL, Mayeux R. Association of Variants in PINX1 and TREM2 With Late-Onset Alzheimer Disease. JAMA Neurol. 2019 May 6. doi: 10.1001/jamaneurol.2019.1066. [Epub ahead of print] PubMed PMID:31058951; PubMed Central PMCID: PMC6503572.