Overview
Description
This is a collaborative study between investigators from the University of Pittsburgh (Pitt) and Washington University (WashU) to delineate the genetic architecture of Alzheimer’s disease (AD) and AD-related proteinopathies. The participants are from a number of genetic studies being carried out on AD and AD-related dementias and non-AD subjects from 1) the Pitt-ADRC and ancillary studies and 2) Knight-ADRC Memory and Aging Project (MAP) study. The study samples are comprised of approximately 90% whites, 10% blacks, and 50% females with a mean age of 77.7 years.
Principal Investigators
- Carlos Cruchaga — Washington University
- Ilyas Kamboh — University of Pittsburgh
Funding Sources
R01 AG064877
Publications
- Olive C. Examination of the Effect of Rare Variants in TREM2, ABI3, and PLCG2 in LOAD Through Multiple Phenotypes. Journal of Alzheimer's disease : JAD. 2020. PubMed link
- Yang C. Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders. Nature neuroscience. 2021 Sep. PubMed link
- Ali M. Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk. PloS one. 2022. PubMed link