LASI-DAD is an in-depth study of late-life cognition and dementia. It draws a sub-sample of 4,000+ LASI respondents aged 60 and older and administers in-depth cognitive tests and informant interviews. LASI is an ongoing cohort study of 72,000 community-residing older adults aged 45 and older and their spouses regardless of…
Cohort Category: ADSP
Stanford Extreme Phenotypes in AD (StEP AD)
This cohort contains samples from Brains for Dementia Research (BDR) Genetics project (Dr. Kevin Morgan, PI and Directory of the Alzheimer’s Research UK (ARUK) DNA Consortium and BDR). The BDR cohort and program was for planned brain donation across five UK brain banks and one donation point, with standardized operating…
Progressive Supranuclear Palsy at the University of California, Los Angeles (PSP UCLA)
This study includes subjects with Progressive Supranuclear Palsy (PSP). Subjects were enrolled in the davenutide PSP Phase Trail 2/3. Additional subjects were clinically diagnosed PSP at the University of California, San Francisco Memory and Aging Center. Participants met the modified Neuroprotection and Natural History in Parkinson Plus Syndrome study criteria…
University of Pittsburgh (PITT)
Study participants were enrolled at the University of Pittsburgh Alzheimer’s Disease Research Center (ADRC), all of whom met the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association clinical criteria for probable AD. Each participant had undergone an extensive neuropsychiatric evaluation, which has been described in…
Puerto Rican 10/66 Study (PR1066)
The Puerto Rican 10/66 Study (PR1066) (https://www.alz.co.uk/1066/), is an Alzheimer’s Disease International study of dementia in Puerto Rico that began in 2007 (Dr. Ivonne Jimenez-Velazquez, PI). Individuals were recruited as part of the the 10/66 Population Based Study of Dementia using standard protocols. As part of this study, sociodemographic information and…
Mount Sinai Brain Bank (MSBB)
Human brains were accessed from the Mount Sinai/JJ Peters VA Medical Center Brain Bank (MSBB–Mount Sinai NIH Neurobiobank) cohort, which holds over 2,040 well-characterized brains. This cohort was assembled after applying stringent inclusion/exclusion criteria and represents the full spectrum of cognitive and neuropathological disease severity in the absence of discernable…
Cache County Study (CCS)
The Cache County Study on Memory Health and Aging (CCS) was initiated in 1994 to investigate the association of APOE genotype and environmental exposures on cognitive function and dementia. This cohort of 5092 Cache County, Utah, residents (90% of those aged 65 years or older in 1994), has been followed…
Corticobasal Degeneration (CBD)
Patients with a clinical Parkinsonism in life and neuropathological confirmation of Corticobasal Degeneration (CBD) were identified from brain banks, research hospitals and neuropathologists. The top three contributing sites were the Mayo Clinic, University College London, and the University of Pennsylvania and additional small numbers of cases were obtained from various…
University of Washington Families (RAS)
131 families with LOAD (751 individuals) were ascertained and evaluated through the University of Washington Alzheimer Disease Research Center. Clinical and neuropathological assessments of cases and controls, including blood sampling, medical record reviews, brain autopsies, and genetic analyses were performed under protocols approved by the institutional review boards of the…
University of Toronto (TOR)
This study was carried out under the direction of Dr. Peter St George-Hyslop and Dr Rogaeva at the Tanz Centre for Research in Neurodegenerative Diseases (CRND), University of Toronto. In order to explore the potential role of hereditary factors, a registry at the Tanz CRND with a coordinator was established…