We collected and analyzed genomic sequencing data from individuals with clinician-diagnosed early-onset or atypical dementia and, in many cases, their family members. One hundred total patients were described. Pathogenic variants, as well as established risk variants, were returned to patients. A polygenic risk score (PRS) was calculated for Alzheimer’s patients…
Cohort Country: United States of America
The Movement Disorder Clinic (MDC)
The Movement Disorder Clinic (MDC) at Washington University in Saint Louis (St. Louis, MO, USA) recruits and assess longitudinally participants with movements disorders. The Genetics of the Parkinson’s Disease study involved longitudinal collection of biofluids, clinical assessments, neuropsychological testing, neuroimaging, and, for those willing to donate the brain upon death,…
SEA-AD
Postmortem brain tissue and donor metadata were obtained via the UW BioRepository and Integrated Neuropathology (BRaIN) laboratory from participants in the Kaiser Permanente Washington Health Research Institute ACT Study and the University of Washington ADRC. The study cohort was selected based solely on donor brains undergoing precision rapid procedure (optimized…
Resource for Early-onset Alzheimer’s Disease Research (READR)
The READR project recruited families assumed to be multiply affected by early-onset AD by history or autopsy across the United States. The criteria for study entry included two living siblings affected by early-onset AD, 35 years of age or older, and a third living elderly relative without cognitive impairment. We…
The Sacramento Area Latino Study on Aging (SALSA)
The Sacramento Area Latino Study on Aging (SALSA) is a population-based, prospective study of foreign and US-born Latino respondents living in the Sacramento Valley region of Northern California. The SALSA study is tracking the incidence of physical and cognitive impairment as well as dementia and cardiovascular diseases in elderly Latinos…
Brain Amyloid Cognitive Normal Elders Study (BACNE)
Please reach out to Dr. Ilyas Kamboh, University of Pittsburgh, for more information.
Human Connectome Project
Please reach out to Dr. Ilyas Kamboh, University of Pittsburgh, for more information.
The Monongahela-Youghiogheny Healthy Aging Team (MYHAT)
Mild Cognitive Impairment: A Prospective Community Study. The Monongahela-Youghiogheny Healthy Aging Team study is supported in part by the National Institute on Aging under research grant R01 AG023651. The MYHAT project seeks to describe the distribution of Mild Cognitive Impairment (MCI) and related entities, their associated features, their outcomes over…
Heart SCORE
Bambs CE, Kip KE, Mulukutla SR, Aiyer AN, Johnson C, McDowell LA, Matthews K, Reis SE. Sociodemographic, clinical, and psychological factors associated with attrition in a prospective study of cardiovascular prevention: the Heart Strategies Concentrating on Risk Evaluation study. Ann Epidemiol. 2013 Jun;23(6):328-33. doi: 10.1016/j.annepidem.2013.02.007. Epub 2013 Mar 25. PMID:…
The Ginkgo Evaluation of Memory Study
U01 AT000162 from the National Center for Complementary and Alternative Medicine. DeKosky ST, Fitzpatrick A, Ives DG, Saxton J, Williamson J, Lopez OL, Burke G, Fried L, Kuller LH, Robbins J, Tracy R, Woolard N, Dunn L, Kronmal R, Nahin R, Furberg C; GEMS Investigators. The Ginkgo Evaluation of Memory…