The Case Western Reserve University (CWRU) Autopsy Cohort was an Alzheimer’s Disease Research Center (ADRC) clinic-based sample. Subjects included in the Case Western Reserve Autopsy cohort include individuals who were participants in the Brain Health and Memory Center Research Brain Donation Protocol at University Hospitals Cleveland Medical Center in Cleveland,…
Cohort Country: United States of America
Amish Protective Variant Study
The Amish Protective Variant Study, based at Case Western Reserve University and the University of Miami (Cummings et al. 2012; D’Aoust et al. 2015), is being conducted in the Indiana and Ohio Old Order Amish (OOA) population. The OOA, an isolated founder population originating from emigration of German and Swiss…
Cuban American Alzheimer’s Disease Initiative (CuAADI)
The Cuban American Alzheimer’s Disease Initiative (CuAADI) is a convenience sample ascertained through community outreach to Alzheimer’s and adult day care centers in Southern Florida, lay conferences, and Neurology and Memory Disorders clinics. Eligibility was based on self-reported Cuban heritage. The participants were recruited in South Florida which is home to the…
Case Western Reserve University (CWRU) Rapid Decline
The Case Western Reserve University (CWRU) Rapid Decline Cohort (Cohen et al. 2015) represents patients with rapid decline. Subjects included in the Case Western Reserve Rapid Decline dataset include individuals who were initially suspected of having Creutzfelt-Jakob disease (CJD). The Brains of these individuals were obtained by the National Prion…
Wisconsin Registry for Alzheimer’s Prevention (WRAP)
The Wisconsin Registry for Alzheimer’s Prevention (WRAP) is an ongoing longitudinal observational cohort study of individuals age 40-65 at baseline who do not have dementia. Since 2001, WRAP has enrolled more than 1,700 individuals, 73% of whom had a parental history of probable Alzheimer’s disease (AD) dementia. Participants return for…
NIH Neurobiobank/University of Maryland (UMB-BTB)
The National Institutes of Health have established and funded a network of six Brain and Tissue Banks referred to as the NIH NeuroBioBank. Each of the banks collects and distributes tissue from donors with neurodevelopmental, neurodegenerative, and psychiatric disorders as well as control donors lacking any clinical brain diagnosis. The…
Massachusetts Alzheimer’s Disease Research Center (MassADRC)
The Massachusetts Alzheimer’s Disease Research Center (MADRC) is a P30 research center funded by the National Institute on Aging. Our center has been at the forefront of dementia research, treatment and care since 1984.Our expert staff from both Mass General Hospital and Brigham and Women’s Hospital work closely together under…
Clinical and Pathological Studies in the Oldest Old (90+ Study)
The 90+ Study is one of the largest studies of the oldest-old in the world. More than 1,600 people have enrolled. Initial participants in The 90+ Study were once members of The Leisure World Cohort Study (LWCS), which was started in 1981. Participants of The 90+ Study are visited every…
Health and Retirement Study (HRS)
The HRS is a nationally representative sample with oversamples of African-American and Hispanic populations. The target population for the original HRS cohort includes all adults in the contiguous United States born during the years 1931–1941 who reside in households. HRS was subsequently augmented with additional cohorts in 1993 and 1998…
Microglia Genomic Atlas – Neuropathology Brain Bank at Mount Sinai Hospital (MiGA MSSM)
Research conducted using human post-mortem brain tissue remains a critical component of translational brain research programs. To meet the urgent need for this precious resource, the Neuropathology Brain Bank and Research CoRE was launched as part of the Mount Sinai Strategic Plan in July 2018.The neuropathology brain bank is focused…