The Research in African-American Alzheimer’s Disease Initiative (REAAADI) is a NIH NIA study focused on identifying genetic factors for Alzheimer disease within the African-American population in order to detect new targets for drug development and improve accessibility to Alzheimer’s disease education within the community. Participants were ascertained for multiple studies of AD/ADRD…
Cohort Country: United States of America
University of Miami Brain Bank (MBB)
The University of Miami Brain Bank Cohort was ascertained through self-referred cases and controls to the University of Miami Brain Endowment Bank, a National Institutes of Health (NIH) NeuroBioBank, one of six designated brain and tissue biorepositories in the nation. Medical records are available on all cases and controls, all…
Case Western Reserve University (CWRU) Autopsy
The Case Western Reserve University (CWRU) Autopsy Cohort was an Alzheimer’s Disease Research Center (ADRC) clinic-based sample. Subjects included in the Case Western Reserve Autopsy cohort include individuals who were participants in the Brain Health and Memory Center Research Brain Donation Protocol at University Hospitals Cleveland Medical Center in Cleveland,…
Amish Protective Variant Study
The Amish Protective Variant Study, based at Case Western Reserve University and the University of Miami (Cummings et al. 2012; D’Aoust et al. 2015), is being conducted in the Indiana and Ohio Old Order Amish (OOA) population. The OOA, an isolated founder population originating from emigration of German and Swiss…
Cuban American Alzheimer’s Disease Initiative (CuAADI)
The Cuban American Alzheimer’s Disease Initiative (CuAADI) is a convenience sample ascertained through community outreach to Alzheimer’s and adult day care centers in Southern Florida, lay conferences, and Neurology and Memory Disorders clinics. Eligibility was based on self-reported Cuban heritage. The participants were recruited in South Florida which is home to the…
Case Western Reserve University (CWRU) Rapid Decline
The Case Western Reserve University (CWRU) Rapid Decline Cohort (Cohen et al. 2015) represents patients with rapid decline. Subjects included in the Case Western Reserve Rapid Decline dataset include individuals who were initially suspected of having Creutzfelt-Jakob disease (CJD). The Brains of these individuals were obtained by the National Prion…
Wisconsin Registry for Alzheimer’s Prevention (WRAP)
The Wisconsin Registry for Alzheimer’s Prevention (WRAP) is an ongoing longitudinal observational cohort study of individuals age 40-65 at baseline who do not have dementia. Since 2001, WRAP has enrolled more than 1,700 individuals, 73% of whom had a parental history of probable Alzheimer’s disease (AD) dementia. Participants return for…
NIH Neurobiobank/University of Maryland (UMB-BTB)
The National Institutes of Health have established and funded a network of six Brain and Tissue Banks referred to as the NIH NeuroBioBank. Each of the banks collects and distributes tissue from donors with neurodevelopmental, neurodegenerative, and psychiatric disorders as well as control donors lacking any clinical brain diagnosis. The…
Massachusetts Alzheimer’s Disease Research Center (MassADRC)
The Massachusetts Alzheimer’s Disease Research Center (MADRC) is a P30 research center funded by the National Institute on Aging. Our center has been at the forefront of dementia research, treatment and care since 1984.Our expert staff from both Mass General Hospital and Brigham and Women’s Hospital work closely together under…
Clinical and Pathological Studies in the Oldest Old (90+ Study)
The 90+ Study is one of the largest studies of the oldest-old in the world. More than 1,600 people have enrolled. Initial participants in The 90+ Study were once members of The Leisure World Cohort Study (LWCS), which was started in 1981. Participants of The 90+ Study are visited every…