Cohort Country: United States of America

This study includes subjects with Progressive Supranuclear Palsy (PSP). Subjects were enrolled in the davenutide PSP Phase Trail 2/3. Additional subjects were clinically diagnosed PSP at the University of California, San Francisco Memory and Aging Center. Participants met the modified Neuroprotection and Natural History in Parkinson Plus Syndrome study criteria…

Study participants were enrolled at the University of Pittsburgh Alzheimer’s Disease Research Center (ADRC), all of whom met the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association clinical criteria for probable AD. Each participant had undergone an extensive neuropsychiatric evaluation, which has been described in…

Human brains were accessed from the Mount Sinai/JJ Peters VA Medical Center Brain Bank (MSBB–Mount Sinai NIH Neurobiobank) cohort, which holds over 2,040 well-characterized brains. This cohort was assembled after applying stringent inclusion/exclusion criteria and represents the full spectrum of cognitive and neuropathological disease severity in the absence of discernable…

The Cache County Study on Memory Health and Aging (CCS) was initiated in 1994 to investigate the association of APOE genotype and environmental exposures on cognitive function and dementia. This cohort of 5092 Cache County, Utah, residents (90% of those aged 65 years or older in 1994), has been followed…

131 families with LOAD (751 individuals) were ascertained and evaluated through the University of Washington Alzheimer Disease Research Center.  Clinical and neuropathological assessments of cases and controls, including blood sampling, medical record reviews, brain autopsies, and genetic analyses were performed under protocols approved by the institutional review boards of the…

Data from the Texas Alzheimer’s Research and Care Consortium (TARCC) includes cases enrolled at several major medical research institutions (as of 2013 this included Baylor College of Medicine, Texas Tech University Health Sciences Center, University of North Texas Health Science Center, The University of Texas Health Sciences Center at San…

The Religious Orders Study (ROS) is a longitudinal, epidemiologic clinical-pathological study of memory, motor, and functional problems in older Catholic nuns, priests, and brothers aged 65 years and older from across the United States. Participants without known dementia agree to medical and psychological evaluation each year and brain donation after…

Case studies generated for members of this cohort include clinical data regarding onset and progression of cognitive problems, medical history and medications, family history of memory problems, neurological history and examination results, psychiatric history and examination results, neuropsychological examination results, and diagnostic imaging and laboratory results. In addition to demographic…