Description

These data include a total of 18,916 subjects from the Health and Retirement Study genotyped on Illumina HumanOmni2.5-arrays.  Data files also include imputed data using the 1000 Genomes and the Haplotype Reference Consortium (HRC) reference panels.

Respondents who consented to the saliva collection in 2006 (Phase 1), 2008 (Phase 2), 2010 (Phase 3), or 2012 (Phase 4) have been genotyped using Illumina Omni genotyping platforms. The Phase 1 and 2 participants were genotyped together, and were imputed together previously (see dbGaP accession number phs000428.v1.p1). The Phase 3 participants were subsequently genotyped, and were imputed together with Phases 1-2 (dbGaP accession number phs000428.v2.p2). An additional 3,303 Phase 4 participants were genotyped in 2015, and were imputed together with Phases 1-3, yielding a total of 18,923 unique HRS participants: 15,620 from Phases 1-3, and 3,303 from Phase 4.  After QC, there were a total of 18,916 unique HRS participants included in this dataset.

APOE phenotype data for HRS subjects is available at NG00132 – Health and Retirement Study (HRS) APOE and Serotonin Transporter Alleles, and DNA methylation data for HRS subjects is available at NG00153 – Health and Retirement Study (HRS) DNA Methylation.  To obtain subject ID mapping between HRS datasets, please submit a Genetic Data Cross-Reference Request Form on the HRS website.

Additional information can be found on the HRS website: https://hrs.isr.umich.edu/data-products/genetic-data

Sample Summary per Data Type

Sample SetAccessionData TypeNumber of Samples
HRS-All Phasessnd10027GWAS, 1000G Imputation, HRC Imputation19,004
HRS-Phase 4snd10028GWAS3,475

Available Filesets

FilesetAccessionLatest ReleaseDescription
HRS GWASfsa000020NG00119.v1GWAS Illumina HumanOmni2.5
HRS Imputationfsa000021NG00119.v11000G Imputation data, HRC Imputation data

View the File Manifest for a full list of files released in this dataset.