Description
Provided here are variant calls in VCF format for 14,526 samples derived from the ADSP whole-exome and whole-genome sequencing dataset (available via DSS: NG00067).
Cohorts
- Adult Changes in Thought (ACT)
- Atherosclerosis Risk in Communities (ARIC)
- Cardiovascular Health Study (CHS)
- Chicago Health and Aging Project (CHAP)
- Erasmus Rucphen Family (ERF)
- Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA)
- Framingham Heart Study (FHS)
- Genetic Differences (GenDiff)
- Mayo Clinic (MAYO)
- Multi-Institutional Research in Alzheimer's Genetic Epidemiology (MIRAGE)
- National Centralized Repository for Alzheimer’s Disease and Related Dementias Family (NCRAD Family)
- National Institute of Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS)
- NIA Alzheimer's Disease Research Centers (ADRC)
- Religious Orders Study/Memory and Aging Project (ROSMAP)
- Rotterdam Study (RS)
- Texas Alzheimer’s Research and Care Consortium (TARCC)
- University of Miami (MIA)
- University of Toronto (TOR)
- University of Washington Families (RAS)
- Vanderbilt University (VAN)
- Washington Heights and Inwood Community Aging project (WHICAP)
Sex
Total number of samples: 14,526
Female 8,718 60.0 %
Male 5,786 39.8 %
Race
Total number of samples: 14,526
| American Indian/Alaska Native | 2 |
| Native Hawaiian or Other Pacific Islander | 1 |
| Black or African American | 1,024 |
| White | 11,954 |
| Other | 1,520 |
| NA | 25 |
Ethnicity
Total number of samples: 14,526
Not Hispanic or Latino
12,462
85.8%
Hispanic or Latino
1,926
13.3%
Not Applicable/Not Available
138
1.0%
Diagnosis
Total number of samples: 14,526
| AD | ||
|---|---|---|
| Control | 6,032 | 41.5% |
| Case | 7,741 | 53.3% |
| Other | 9 | 0.1% |
| Unknown | 722 | 5.0% |
| NA | ||
|---|---|---|
| Unknown | 22 | 0.2% |
APOE
Total number of samples: 14,526
- 2286 (0.6%)
- 231,629 (11.2%)
- 24287 (2.0%)
- 338,156 (56.1%)
- 343,975 (27.4%)
- 44363 (2.5%)
- NA30 (0.2%)